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Treatment of Bronchiolitis by Air Compression Pump Inhalation and Ultrasonic Atomization
ã€Abstract】 Objective: To compare the therapeutic effects of air compression pump inhalation and ultrasonic atomization inhalation on pediatric bronchiolitis. Methods: A total of 120 children with bronchiolitis were randomly divided into treatment group and control group, 60 cases in each group. Both groups were given anti-infection and other routine treatment. At the same time, patients in treatment group were inhaled with salbutamol and budesonide , Ipratropium bromide; the control group with the same kind of drugs inhaled inhalation therapy to observe changes in the disease. Results: The treatment group with air compression pump atomization inhalation treatment is better, compared with the control group ultrasonic atomization inhalation difference was statistically significant (P Keywords: air compression pump; ultrasonic atomization; bronchiolitis The The Therapeutic Effect Observation of Air Compressor Pump Inspiration and Ultrasound Atomization on Bronchiolitis Abstract: Objective To explore the clincal effects of air compressor pump inspiration and ultrasound atization on children bronchiolitis. Methods 120 children who had bronchiolitis were divided into treatment group and control group at random, with 60 children in each group. All groups underwent the anti-infection and other routine treatments. Meanwhile, the children in treatment group inhalated salbutamol, budesonide and ipratropium bromide with the accessory measure of compression aerosol, while children in control group inhalated the same drugs with the ultrasound atomization. The changes of patients' condition were observed. Results The clinical results were better in the treatment group and had significant differece compared with the control group. Bronchiolitis is a common respiratory disease in infancy, more common in infants under 2 years of age, especially For 1 month to 6 months of infants, most of the pathogens are respiratory syncytial virus to cough, wheezing, fever or fever, shortness of breath, nasal flap, cyanosis, three concave signs obvious auscultation wheeze and fine Wet rales and other clinical manifestations, severe concurrent heart failure, respiratory failure and so on. Our department from October 2002 to October 2005 of 120 cases of children with bronchiolitis in oxygen, anti-inflammatory, correct acidosis, sedation and hormone treatment based on the comprehensive observation of the comparison of air compression pump inhalation and ultrasonic fog Therapeutic effect of inhalation on pediatric bronchiolitis is reported below. 1 Materials and Methods 1.1 General Information 120 patients were hospitalized children, according to "Practical Pediatrics," the sixth edition of the diagnostic criteria consistent with bronchiolitis diagnostic criteria [1], were randomly divided into treatment group 60 patients, 32 males , 28 females; aged 4 months to 2 years, an average of 7 months. The control group of 60 patients, 27 males and 33 females; aged 4 months to 2 years, an average of 7 months. All 120 patients had fever, cough, asthma and pulmonary rales to varying degrees. There was no significant difference between the two groups in age and comparability. 1.2 Methods The treatment group was given salbutamol 1.25 mg, budesonide 0.5 mg, ipratropium bromide 250 μg, and normal saline to 3 ml on the basis of conventional treatment of oxygen, anti-inflammatory, correct acidosis, sedation and hormones Air compression pump inhalation, each about 10 min, 3 times / d, once every 3 d ~ 10 d. The control group with the same kind of drugs to inhalation of ultrasonic inhalation therapy, changes in the hand observed by hand every day and record. 1.3 curative effect markedly relieved symptoms within 3 d, wheezing, dyspnea, hypoxia and other performance improved significantly, lung wheezing disappeared, blood gas analysis was normal, chest X-ray significantly improved; effective: 5 d alleviate the symptoms , Breathless breathing difficulty, hypoxia basically returned to normal, wheeze also disappeared, blood gas analysis returned to normal, chest X-ray improved; invalid: 7 d within a variety of symptoms and signs were not significantly improved, blood gas analysis is not normal, chest X-ray No improvement, or even worse. 1.4 Statistical Analysis Counting data using χ2 detection. 2 results in the treatment group markedly effective in 52 cases (86.7%), effective in 6 cases (10.0%), the total effective rate was 96.7%; control group markedly effective in 32 cases (53.3%), effective in 10 cases (16.7% 70.0%), see Table 1. Statistical differences between the two groups were statistically significant (P 3 discussion of bronchiolitis is a common lower respiratory tract infection in children, the lesion mainly invading the capillary diameter of 75 μm ~ 300 μm, the mucus secretion, lymphocyte infiltration , Cell destruction and clogging of cellulose and epithelial cell necrosis.1 Some of the children with elevated plasma P-cell concentration, causing bronchial smooth muscle contraction spasm and airway hyperresponsiveness.As soon as possible to improve the symptoms of pulmonary function recovery for the purpose of the traditional method Anti-inflammatory, anti-asthma, cough, phlegm, fever and other treatment; severe asthma given oxygen and intravenous adrenal cortex hormones treatment, children often have more airway sputum, airway narrowing, such as systemic hormones are more Many side effects make some children worse.Using passive inhalation therapy, the liquid spray, spray directly into the target organ of the respiratory tract, and quickly play a role. Has a strong effect, rapid onset, small doses, less side effects and so on. Due to β2 receptors mainly distributed in the surrounding small trachea, and with the airway diameter becomes smaller density; and cholinergic receptors are mainly distributed in small Road proximal salbutamol is a longer-acting, effective response to β-agonists, ipratropium bromide is an anticholinergics inhalation drugs, not easily absorbed by the body, local action for a long time .Budesonide corticosteroid local Inhalation can reduce airway mucosal edema and reduce its secretion, thereby reducing wheezing symptoms, in the treatment, hormones can increase the number of β2 receptors, increase intracellular cAMP levels, increased β2 agonist bronchodilator effect [2], in addition, hormones As well as anti-inflammatory and regenerative effects on the damaged airway epithelium, thereby reducing airway hyperresponsiveness.All the three inhalation, the drug directly on the airway, relieve airway spasm, reduce secretions, improve ventilation, thereby reducing wheezing Performance, cardiovascular and nervous system side effects are less .As the ultrasonic atomizer mist diameter of 5μm ~ 10μm, it is generally only inhaled to the patient's throat, trachea, bronchioles to the very few; and air Compression pump fog particles generated by 3 μm ~ 5 μm can reach the bronchioles and bronchioles, so the role of good, the effect is more obvious. 1.4 statistical processing count 2 results in the treatment group was significantly improved in 52 cases (86.7%), effective in 6 cases (10.0%), the total effective rate was 96.7%; control group markedly 32 cases (53.3%), effective in 10 cases (16.7% The effective rate was (70.0%), see Table 1. The two groups were statistically significant differences in treatment (P 3 discussion bronchiolitis is a common lower respiratory tract infection in children, the lesion mainly affects the diameter of 75 μm ~ 300 μm capillary Bronchial, increased mucus secretion, lymphocytic infiltration, cell destruction and clogging of cellulose and epithelial cell necrosis [1] .Partial children with elevated plasma P-cell concentration, bronchial smooth muscle contraction spasm and airway hyperresponsiveness As soon as possible to improve the symptoms of recovery of lung function for the purpose of the traditional methods of anti-inflammatory, anti-asthma, cough, phlegm, fever and other treatment; severe asthmatic given oxygen and intravenous adrenal cortical hormone therapy, Many, narrow airway, such as systemic hormones have more side effects so that some children worse. Passive inhalation therapy, the liquid spray, spray directly into the respiratory target organ, quickly play a role. Has strong effects, rapid onset, small amount of medication, fewer side effects and so on. As β2 receptors are mainly located in the surrounding small trachea, and with the airway diameter becomes smaller density; and cholinergic receptors are mainly located in the proximal small airways. Salbutamol is a longer-acting, potent beta-agonist, and ipratropium bromide is an anticholinergically topically-inhaled drug that is not readily absorbed by the body and has a long-lasting effect. Budesonide corticosteroids local inhalation can reduce airway mucosal edema and reduce its secretion, thereby reducing the symptoms of wheezing, in the treatment, hormones can increase the number of β2 receptors, increase intracellular cAMP levels and increase β2 agonist bronchodilator [ 2], in addition, hormones also damage the airway epithelium anti-inflammatory and regeneration, thereby reducing airway hyperresponsiveness